dicer | Dicer - Wikipedia

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Dicer - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/Dicer

WEBDicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA , respectively.

DA: 43 PA: 80 MOZ Rank: 50

DICER: structure, function, and regulation - PMC - National …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724510/

WEBNov 16, 2021 · DICER is at the cornerstone of most biological processes; hence, its mRNA and protein levels are subject to multiple layers of regulation. Accordingly, DICER derangement is related to disease and leads to accelerated aging. Interventions that boost DICER function hold great potential as strategies to promote health and longevity.

DA: 72 PA: 77 MOZ Rank: 55

Molecular mechanisms of Dicer: endonuclease and enzymatic …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415849/

WEBMay 5, 2017 · Abstract. The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional small RNAs derived from various sources.

DA: 3 PA: 68 MOZ Rank: 87

Dicer - an overview | ScienceDirect Topics
sciencedirect.com

https://www.sciencedirect.com/topics/neuroscience/dicer

WEBDicer, the ribonuclease crucial for microRNA biogenesis, is encoded in humans by the DICER1 gene. It is a multi-domain RNA-binding protein [ 111] belonging to the family of type III RNAse enzymes. Dicer dysfunctions and abnormal microRNA processing have been linked to aging and various ND diseases [ 112–116 ].

DA: 86 PA: 40 MOZ Rank: 17

DICER: structure, function, and regulation - PubMed
nih.gov

https://pubmed.ncbi.nlm.nih.gov/35059029/

WEBNov 16, 2021 · Interventions that boost DICER function hold great potential as strategies to promote health and longevity. In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms having an impact on DICER abundance and function.

DA: 72 PA: 73 MOZ Rank: 66

Structure of the human DICER–pre-miRNA complex in a dicing state
nature.com

https://www.nature.com/articles/s41586-023-05723-3

WEBFeb 22, 2023 · Human DICER (hDICER, also known as DICER1) is specialized for cleaving small hairpin structures such as precursor microRNAs (pre-miRNAs) and has limited activity towards long dsRNAs—unlike its...

DA: 58 PA: 59 MOZ Rank: 8

Dicer structure and function: conserved and evolving features
embopress.org

https://www.embopress.org/doi/full/10.15252/embr.202357215

WEBJun 13, 2023 · Dicer is a general name for RNase III endoribonucleases producing small RNAs for RNA silencing pathways. There is a common order of specific modules present in Dicer across eukaryotic kingdoms, which reflects the common order of protein domains in the primary protein sequence.

DA: 16 PA: 30 MOZ Rank: 18

RNA interfering machinery: new insight into the Dicer-2 ... - Nature
nature.com

https://www.nature.com/articles/s41392-022-01272-9

WEBJan 2, 2023 · siRNAs are a crucial component for RNA interference (RNAi), a well-known gene expression regulation mechanism in various eukaryotes. Dicer, an RNase III enzyme, has a central role in producing...

DA: 26 PA: 9 MOZ Rank: 50

DICER1: mutations, microRNAs and mechanisms - Nature
nature.com

https://www.nature.com/articles/nrc3802

WEBSep 1, 2014 · Dicer is central to microRNA-mediated silencing and several other RNA interference phenomena that are profoundly embedded in cancer gene networks. Most recently, both germline and somatic...

DA: 30 PA: 80 MOZ Rank: 58

A Glimpse of “Dicer Biology” Through the Structural and …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138440/

WEBMay 7, 2021 · Dicer, an RNase III enzyme, initiates the RNAi pathway, plays a pivotal role in fighting infection against pathogens, and acts as a housekeeping enzyme for cellular homeostasis. Here, we review structure-based functional insights of Dicer and its domains present in a diverse group of organisms.

DA: 70 PA: 1 MOZ Rank: 50