A clinician’s guide to understanding resistance to thyroid hormone due
https://clindiabetesendo.biomedcentral.com/articles/10.1186/s40842-017-0046-z
WebSep 15, 2017 · There are two genes that express the major thyroid hormone receptor isoforms. Mutations in both these genes have given rise to Resistance to Thyroid Hormone (RTH) syndromes (RTHβ, RTHα) that can have variable phenotypes for mutations of the same receptor isoform as well as between the two receptor isoforms. In general, the relative tissue-specific distribution of TRβ and TRα determine RTH ...
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