A gene-environment-induced epigenetic program initiates
https://pubmed.ncbi.nlm.nih.gov/33536616/
Tissue damage increases the risk of cancer through poorly understood mechanisms 1.In mouse models of pancreatic cancer, pancreatitis associated with tissue injury collaborates with activating mutations in the Kras oncogene to markedly accelerate the formation of early neoplastic lesions and, ultimately, adenocarcinoma 2,3.Here, by integrating genomics, single-cell chromatin …
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