BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis …
https://www.embopress.org/doi/10.15252/embj.2021108690
WebDec 21, 2021 · During apoptosis, the BCL‐2‐family protein tBID promotes mitochondrial permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 members. Here, we report that tBID can also mediate mitochondrial permeabilization by itself, resulting in release of cytochrome c and mitochondrial DNA, caspase activation and apoptosis ...
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