Avoid foods high in Vitamin K, e.g. large amounts of leafy green vegetables and some vegetable oils. May need to avoid alcohol, cranberry juice, and products containing cranberries. Click to see full answer. Similarly, can you take apixaban with food?What are the interactions between apixaban and other drugs?
Apixaban Drug Interaction Potential. Pharmacodynamic Interactions. The concurrent use of apixaban with other anticoagulants, antiplatelet agents, and nonsteroidal anti-inflammatory agents is expected to increase the risk of bleeding in comparison to use of apixaban alone.How does P-gp affect the absorption of apixaban?
P-gp inhibitors can increase the absorption of apixaban, increasing both AUC and Cmax. Conversely, P-gp inducers can reduce the absorption of apixaban, decreasing AUC and Cmax. 2. The metabolism of apixaban is mediated by CYP3A4.How does carbamazepine decrease the level of apixaban?
Therapeutic duplication; may use temporarily when switching anticoagulants. carbamazepine will decrease the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Reduces anticoagulant effect by decreasing apixaban systemic exposure