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What is the function of the ASXL1 gene?

The ASXL1 gene provides instructions for making a protein that is involved in a process known as chromatin remodeling. Chromatin is the complex of DNA and proteins that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged.

Are there any clinical trials with ASXL1 status?

ASXL1 is an inclusion criterion in 1 clinical trial for colorectal carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ASXL1 status and colorectal carcinoma as inclusion criteria, 1 is phase 1 (1 open) [4].

What is the Putative Polycomb group protein ASXL1?

Putative Polycomb group protein ASXL1 is a protein that in humans is encoded by the ASXL1 gene. In Drosophila, the Additional sex combs (Asx) gene encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo.

Is the ASXL1 mutation a bona fide mutation?

ASXL1 and concomitant mutations in myeloid malignancies. One study has described this mutation as a PCR artefact [ 19 ], but because it is not found in germ-line DNAs, control DNAs or other studied types of cancers such as breast cancer, it is now generally considered to be a bona fide mutation.


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