Keyword Analysis & Research: asxl1 exons

biomedcentral.com

https://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-5-12

DA: 30 PA: 27 MOZ Rank: 21

ashpublications.org

https://ashpublications.org/blood/article/126/23/1673/134991/Prognostic-Impact-of-ASXL1-Mutations-in-MDS-and

WEBMar 21, 2012 · ASXL1 comprises 12 exons and is expressed in most hematopoietic cell types. Function of the ASXL1 protein. ASXL1 codes for a nuclear protein of 1084 residues … Author: Véronique Gelsi-Boyer, Mandy Brecqueville, Mandy Brecqueville, Raynier Devillier, Raynier Devillier,... Publish Year: 2012

Author: Véronique Gelsi-Boyer, Mandy Brecqueville, Mandy Brecqueville, Raynier Devillier, Raynier Devillier,...

Publish Year: 2012

DA: 48 PA: 74 MOZ Rank: 84

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364143/

WEBASXL1 mutations frequently coexist with other mutations, such as TET2 , RUNX1 , SETBP1 (49–51) and NRAS (25–28). Asxl1 loss in mice results in MDS that could transform to … DOI: 10.1016/j.exphem.2022.09.003 Published: 2022/11

DOI: 10.1016/j.exphem.2022.09.003

Published: 2022/11

DA: 22 PA: 64 MOZ Rank: 56

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450349/

WEBSep 6, 2022 · Most ASXL1 mutations in myeloid malignancies are frameshift or nonsense mutations in exon 12 (last exon) before the PHD finger, enabling the resulting mutant … DOI: 10.1186/s13045-022-01336-x Published: 2022 Publication: J Hematol Oncol. 2022; 15: 127.

DOI: 10.1186/s13045-022-01336-x

Published: 2022

Publication: J Hematol Oncol. 2022; 15: 127.

DA: 44 PA: 35 MOZ Rank: 83

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258702/

WEBJun 12, 2022 · ASXL1 mutations frequently occur in AML patients and cause poor survival. 2, 19 Accordingly, this study aimed to evaluate the frequency of RUNX1 (Exon 8) and ASXL1 … DOI: 10.1111/jcmm.17424 Published: 2022/07 Publication: J Cell Mol Med. 2022 Jul; 26(13): 3797-3801.

DOI: 10.1111/jcmm.17424

Published: 2022/07

Publication: J Cell Mol Med. 2022 Jul; 26(13): 3797-3801.

DA: 87 PA: 71 MOZ Rank: 10

haematologica.org

https://haematologica.org/article/view/haematol.2021.280320

AbstractIntroductionMethodsResultsDiscussionFootnotesReferencesASXL1 mutations are associated with severe disease phenotypes in patients with myelofibrosis ASXL1 mutations are associated with severe disease phenotypes in patients with myelofibrosisTo determine the clinical impact of ASXL1 mutations on MF patients, we analyzed data from 302 MF patients in our single center; 250 (82.8%) patients displayed driver mutations, including 174 (57.6%) JAK2V167F, 63 (20.9%) CALR, and 13 (4.3%) MPL mutations (Online Supplementary Figur… Asxl1 deletion is associated with enhanced extramedullary hematopoiesis in the spleen and onset …To further address the consequences of ASXL1 mutations on MPN in vivo, we utilized Vav1-Cre mice, Asxl1flox/flox and Jak2V617F/+ knockin alleles to achieve hematopoietic cellspecific Jak2V617F/+/Asxl1flox/flox (Asxl1-/-Jak2VF), Jak2V617F/+ (Jak2VF), and Asxl1flox/flox (Asxl1-/-) …

ASXL1 mutations are associated with severe disease phenotypes in patients with myelofibrosisTo determine the clinical impact of ASXL1 mutations on MF patients, we analyzed data from 302 MF patients in our single center; 250 (82.8%) patients displayed driver mutations, including 174 (57.6%) JAK2V167F, 63 (20.9%) CALR, and 13 (4.3%) MPL mutations (Online Supplementary Figur…

Asxl1 deletion is associated with enhanced extramedullary hematopoiesis in the spleen and onset …To further address the consequences of ASXL1 mutations on MPN in vivo, we utilized Vav1-Cre mice, Asxl1flox/flox and Jak2V617F/+ knockin alleles to achieve hematopoietic cellspecific Jak2V617F/+/Asxl1flox/flox (Asxl1-/-Jak2VF), Jak2V617F/+ (Jak2VF), and Asxl1flox/flox (Asxl1-/-) …

DA: 51 PA: 31 MOZ Rank: 7

ashpublications.org

https://ashpublications.org/blood/article/131/3/274/38319/ASXL1-mutations-gain-a-function

WEBJan 18, 2018 · ASXL1 mutation is a gain-of-function mutation. The ASXL1 truncating mutant (ASXL1 aa1-587) but not wt ASXL1 recruit BRD4. BRD4 acetylates H3K122 and activates …

DA: 91 PA: 82 MOZ Rank: 26

nature.com

https://www.nature.com/articles/s41467-021-22053-y

WEBPublished: 23 March 2021. Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. Takeshi Fujino, Susumu …

DA: 89 PA: 8 MOZ Rank: 3

nature.com

https://www.nature.com/articles/leu2012262

WEBPublished: 11 September 2012. Acute Leukemias. ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse …

DA: 87 PA: 70 MOZ Rank: 19

nature.com

https://www.nature.com/articles/s41408-021-00541-0

WEBSep 21, 2021 · A The ASXL1 gene is made up of 12 exons with the ASXL1 G710X mutation in KBM5 cells located in exon 12.

DA: 12 PA: 82 MOZ Rank: 13

nih.gov

https://pubmed.ncbi.nlm.nih.gov/34140438/

WEBPMID: 34140438. Abstract. The ASXL1 (additional sex combs like 1) gene on 20q11 codifies the ASXL1 protein that belongs to protein complexes that play a role in gene expression …

DA: 57 PA: 85 MOZ Rank: 71