Keyword Analysis & Research: langerin

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What is the structure of Langerin?

Langerin is a 40 kDa glycoprotein predominantly N-glycosylated which contains no disulfide bond. Its expression, restricted to the Langerhans cell lineage, is demonstrated at both the surface membrane and in the cytoplasm. Several lines of evidence indicate that Langerin is a marker specific for the acquisition of the Langerhans cell phenotype.

Is Langerin a marker for Langerhans cells?

Test Description Langerin is a highly selective marker for Langerhans cells and the lesional cells of Langerhans cell histiocytosis. Langerin protein expression has utility in differentiating Langerhans cell histiocytosis from other non-Langerhans cell histiocytic proliferations.

What type of lectin is lidlangerin?

Langerin is a type II transmembrane C-type lectin which has mannose-binding specificity. It is a 40 kD protein restricted to Langerhans cells that is involved in the internalization of cell surface material in these immature dendritic cells.


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