Panama Canal Cruises. Ships that cruise the Panama Canal usually go through the first set of locks, then turn around in Gatun Lake and exit the canal the way they entered. Full transits typically sail from coast to coast, beginning in Florida and ending in one of several ports on the West Coast, such as Los Angeles or San Diego (or the reverse).How far is the Panama Canal from Florida?
Distance from Florida to Panama City is 490 kilometers. This air travel distance is equal to 304 miles. The air travel (bird fly) shortest distance between Florida and Panama City is 490 km= 304 miles.