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What does splenomegaly mean?

Splenomegaly is defined as enlargement of the spleen, measured by size or weight.In the past, splenomegaly was a clinical finding, but in recent years, imaging studies have also helped to assess for or confirm mild splenomegaly. The spleen is a functionally diverse organ with active roles in immunosurveillance and hematopoiesis.

What is the primary etiologies of splenomegaly?

Although a wide variety of diseases are associated with enlargement of the spleen, the following six etiologies of splenomegaly are considered primary: Immune response work hypertrophy - Such as in subacute bacterial endocarditis or infectious mononucleosis RBC destruction work hypertrophy - Such as in hereditary spherocytosis or thalassemia major

What is cause splenomegaly?

Causes. The most common causes of splenomegaly in developed countries are infectious mononucleosis, splenic infiltration with cancer cells from a hematological malignancy and portal hypertension (most commonly secondary to liver disease, and sarcoidosis). Splenomegaly may also come from bacterial infections,...

What size is considered splenomegaly?

The standard system for classifying splenomegaly on radiography is: Normal (not splenomegaly): the largest dimension is less than 11 cm. Moderate splenomegaly: the largest dimension is between 11–20 cm. Severe splenomegaly: the largest dimension is greater than 20 cm.

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