Keyword Analysis & Research: splenomegaly mds

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What is splenomegaly and how is it defined?

Splenomegaly refers to enlargement of the spleen. The upper limit of normal adult splenic length is traditionally cited at 12 cm, but lengths upwards of 14 cm can be seen in normal, taller males 7. Massive splenomegaly is variably defined, including when the spleen is 5 standard deviations above the mean normal volume...

What are the symptoms of myelodysplastic syndromes (MDS)?

Symptoms of MDS include a decreased production of red blood cells (anemia) and bleeding caused by a decreased production of platelet cells (thrombocytopenia). Later symptoms include enlargement of the liver (hepatomegaly), enlargement of the spleen (splenomegaly), and swelling of the lymph nodes (lymphadenopathy).

What are the treatment options for an enlarged spleen?

An enlarged spleen itself in an asymptomatic patient needs no treatment unless severe hypersplenism is present. Patients with palpable or very large spleens probably should avoid contact sports and weight-lifting to decrease the risk of splenic rupture. Splenomegaly is almost always secondary to other disorders.

What is the most accurate measurement for splenomegaly in cirrhosis?

On CT, a splenic width measurement (largest anterior-posterior measurement on axial images) of greater than 10.5 cm is the most accurate single measurement for mild to moderate splenomegaly in patients with cirrhosis; while a craniocaudal measurement of greater than 14.6 cm is the most accurate single measurement...

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