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What is the role of STAT4 in Jak?

STAT proteins are a common part of Janus kinase (JAK)- signalling pathways, activated by cytokines.STAT4 is required for the development of Th1 cells from naive CD4+ T cells and IFN-γ production in response to IL-12. There are two known STAT4 transcripts, STAT4α and STAT4β, differing in the levels of interferon-gamma (IFN-γ )production downstream.

Where is STAT4 found in the human body?

Distribution of STAT4 is restricted to myeloid cells, thymus and testis. In resting human T cells it is expressed at very low levels, but its production is amplified by PHA stimulation. Pro-inflammatory cytokine IL-12 is produced in heterodimer form by B cells and antigen-presenting cells.

How long has my club been using stats4sport?

Our club has been using stats4sport for 3 years now. This is our club daily planner, wich uses all employees, including director, managers, coaches, accountant. We collect and save main data. It's an indispensable daily activity tool!

What is the function of STAT4 in Th1 cells?

Signal transducer and activator of transcription 4 ( STAT4) is a transcription factor belonging to the STAT protein family. It is required for the development of Th1 cells from naive CD4+ T cells and IFN-γ production in response to IL-12.


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