Phase II Study of a Weekly 8-Hour 5-Fluorouracil and ...
Abstract. Background: 5-fluorouracil (5-FU) clearly behaves as two different drugs according to the schedules for its administration. A weekly, 8-h 5-FU continuous infusion (CI) regimen may produce a dual effect, because it elicits both a high plasma 5-FU level and also a durable exposure to 5-FU, which may have the advantage of inhibiting both DNA synthesis and RNA activities.
DA: 7 PA: 26 MOZ Rank: 66