Keyword Analysis & Research: the catalogue of somatic mutations in cancer

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Frequently Asked Questions

What does mutation cause cancer?

The most commonly mutated gene in people with cancer is p53 or TP53 . More than 50% of cancers involve a missing or damaged p53 gene. Most p53 gene mutations are acquired. Germline p53 mutations are rare, but patients who carry them are at a higher risk of developing many different types of cancer.

What is somatic cancer?

SOMATIC CANCER | HIGHLIGHTED TESTS. Microsatellite instability (MSI) is a well-recognized phenomenon that is classically a feature of tumors in the hereditary non-polyposis colorectal syndrome. Ten to 15% of sporadic colorectal cancers, however, will have MSI.


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