topoisomerase | Topoisomerase: Types, Structure, Functions, Mechanism

Keyword	CPC	PCC	Volume	Score	Length of keyword
topoisomerase	1.19	1	1692	91	13

Keyword	CPC	PCC	Volume	Score
topoisomerase	1.46	0.1	8046	6
topoisomerase function	0.39	1	4277	45
topoisomerase inhibitors	1.09	1	3548	77
topoisomerase ii	0.04	0.8	4212	44
topoisomerase 1	1.9	0.2	3204	49
topoisomerase iv	1.82	0.3	6383	23
topoisomerase pronunciation	0.38	0.9	2150	33
topoisomerase function in dna replication	1.05	0.1	7221	77
topoisomerase definition	1.3	0.5	9104	37
topoisomerase vs helicase	0.43	0.8	5395	87
topoisomerase 1 vs 2	1.57	0.7	1029	19
topoisomerase 1 inhibitor	0.71	0.8	2879	18
topoisomerase dna replication	1.81	0.2	6231	4
topoisomerase 2 function	1.07	0.6	809	25
topoisomerase ii function	1.99	0.5	3246	24
topoisomerase ii inhibitors	1.35	0.2	8640	84

Search Results related to topoisomerase on Search Engine

Topoisomerase: Types, Structure, Functions, Mechanism
microbenotes.com

https://microbenotes.com/topoisomerase/

WEBFeb 27, 2023 · Topoisomerase is an essential enzyme that aids in the DNA replication process, segregation of chromosomes, transcription, and also in recombination. It was first found by J.C. Wang in the 1970s while working on …

DA: 54 PA: 68 MOZ Rank: 99

Topoisomerase - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/Topoisomerase

WEBarticles. NCBI. proteins. DNA topoisomerases (or topoisomerases) are enzymes that catalyze changes in the topological state of DNA, interconverting relaxed and supercoiled forms, linked (catenated) and unlinked species, and knotted and unknotted DNA.

DA: 79 PA: 75 MOZ Rank: 41

DNA topoisomerases: Advances in understanding of cellular roles …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614492/

WEBApr 4, 2021 · The type IIA topos include prokaryotic DNA gyrase (gyrase) and topoisomerase IV (topo IV), and eukaryotic topoisomerase II (topo II) (Figure 4A). The general mechanism for the type II topos begins with the binding of one DNA duplex, termed the gate segment (G-segment), at the DNA gate.

DA: 68 PA: 3 MOZ Rank: 53

DNA topoisomerases: structure, function, and mechanism
nih.gov

https://pubmed.ncbi.nlm.nih.gov/11395412/

WEBAbstract. DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA. In addition, these enzymes fine-tune the steady-state level of DNA supercoiling both to facilitate protein interactions with the ...

DA: 79 PA: 58 MOZ Rank: 56

Human topoisomerases and their roles in genome stability and
nature.com

https://www.nature.com/articles/s41580-022-00452-3

WEBFeb 28, 2022 · Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A and TOP3B) topoisomerases.

DA: 73 PA: 4 MOZ Rank: 16

DNA Topoisomerases: Structure, Function, and Mechanism
annualreviews.org

https://www.annualreviews.org/content/journals/10.1146/annurev.biochem.70.1.369

WEBDNA Topoisomerases: Structure, Function, and Mechanism. DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA.

DA: 59 PA: 90 MOZ Rank: 38

DNA topoisomerases: Advances in understanding of cellular
nih.gov

https://pubmed.ncbi.nlm.nih.gov/33480441/

WEBAbstract. DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA metabolism. As we review here, current structural approaches have revealed unprecedented insights into the complex DNA-topoisomerase interaction and strand …

DA: 31 PA: 4 MOZ Rank: 84

Cellular roles of DNA topoisomerases: a molecular perspective
nature.com

https://www.nature.com/articles/nrm831

WEBJun 1, 2002 · Escherichia coli DNA topoisomerase III, a type IA enzyme, can support plasmid replication in a purified system 20, but its ability to support DNA chain elongation in vivo is uncertain....

DA: 80 PA: 84 MOZ Rank: 50

All tangled up: how cells direct, manage and exploit topoisomerase
nature.com

https://www.nature.com/articles/nrm3228

WEBNov 23, 2011 · Topoisomerases in replication fork progression. During strand synthesis, topoisomerases are required to relieve the positive supercoiling that arises from DNA unwinding mediated by replicative ...

DA: 95 PA: 7 MOZ Rank: 29

Topoisomerase I in Human Disease Pathogenesis and Treatments
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936607/

WEBMay 12, 2016 · Topoisomerase 1 (TOP1) is a highly conserved enzyme that can be found in both prokaryotes and eukaryotes. In the mammalian system, TOP1 is an essential enzyme for normal development [1] . A major function of TOP1 is to relax supercoiled DNA and alleviate the DNA helical constraints [2] , [3] .

DA: 51 PA: 20 MOZ Rank: 38