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What causes severe thrombocytopenia ( ITP ) in dogs?

Immune-mediated thrombocytopenia (ITP) is an important cause of severe thrombocytopenia in dogs. In patients with ITP, platelet autoantibodies are made and attach to the surface of platelets, targeting them for destruction by macrophages. This results in profound thrombocytopenia,...

What is the treatment for secondary ITP in dogs?

Treatment of secondary ITP should always include treatment of the underlying disease process or discontinuation of the triggering medication.

Are there any adjunctive therapies for ITP patients?

There are several other adjunctive therapies that have more tangible benefits in ITP patients. A single dose of human intravenous immunoglobulin (hIVIG) has been shown to reduce the time to platelet recovery above 40,000 platelets/uL, and to reduce the required hospitalization time in ITP patients.

What are the most common signs of ITP in dogs?

In one study, 81% of dogs presented with signs of bleeding, the most common of which was petechiae or ecchymoses (present in 66% of total ITP cases on presentation).

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